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Bioassay guided fractionation of an ethanol extract of leaves of  Canarium patentinervium  Miq. (Burseraceae Kunth.) led to the isolation of scopoletin. The structure of this coumarin was elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D) and mass spectrometry. Scopoletin inhibited the enzymatic activity of 5-lipoxygenase and acetyl cholinesterase with an IC 50  equal to 1.76 ± 0.01   μ  M and 0.27 ± 0.02 mM, respectively, and confronted oxidation in the ABTS, DPPH, FRAP, and   β  -carotene bleaching assay with EC 50  values equal to 5.62 ± 0.03   μ  M, 0.19 ± 0.01 mM, 0.25 ± 0.03 mM and 0.65 ± 0.07 mM, respectively. Given the aforementioned evidence, it is tempting to speculate that scopoletin represents an exciting scaffold from which to develop leads for treatment of neurodegenerative diseases.

Anti-Inflammatory, Anticholinesterase, and Antioxidant Potential of Scopoletin Isolated fromCanarium patentinerviumMiq. (Burseraceae Kunth)