Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat | Zendy

Deqing Zhang | Zendy; Feng Huang | Zendy; Weichang Chen | Zendy

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Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat

Author(s) -

Deqing Zhang,

Feng Huang,

Weichang Chen

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/731932

Subject(s) - acute pancreatitis , myeloperoxidase , malondialdehyde , saline , oxidative stress , superoxide dismutase , pancreatitis , glutathione , tumor necrosis factor alpha , pathogenesis , medicine , chemistry , inflammation , pharmacology , biochemistry , enzyme

Oxidative stress plays an important role in the pathogenesis of acute pancreatitis (AP). As an ideal exterminator of poisonous free radicals, hydrogen can clearly reduce the degree of oxidative damage caused by severe acute pancreatitis (SAP) and lessen the presence of inflammatory cytokines. The aim of this study was to investigate the effects and mechanism of hydrogen-rich saline on SAP in rats. Serum TNF- α , IL-6, and IL-18 and histopathological score in the pancreas were reduced after hydrogen-rich saline treatment. Malondialdehyde (MDA) and myeloperoxidase (MPO) contents were obviously reduced, while superoxide dismutase (SOD) and glutathione (GSH) contents were increased after hydrogen-rich saline treatment. The expression of mRNA of tumor necrosis factor- α (TNF- α ) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas was reduced in hydrogen-rich saline treated group. In conclusion, intravenous hydrogen-rich saline injections could attenuate the severity of AP, probably via inhibiting the oxidative stress and reducing the presence of inflammatory mediators.

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