Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization | Zendy

Roman Günthner | Zendy; HansJoachim Anders | Zendy

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Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization

Author(s) -

Roman Günthner,

HansJoachim Anders

Publication year - 2013

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/2013/731023

Subject(s) - mononuclear phagocyte system , irf8 , interferon regulatory factors , phenotype , macrophage polarization , microbiology and biotechnology , interferon , biology , transcription factor , cd163 , phagocyte , intracellular , macrophage , irf5 , homeostasis , immunology , gene , genetics , phagocytosis , in vitro

The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization.

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