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We have tested serum samples from 24 patients with multifocal motor neuropathy (MMN) for reactivity to ganglioside GM1 and to Gal(  β  1–3)GalNAc-bearing glycoproteins isolated from human peripheral nerve and from  Campylobacter jejuni  ( Cj ) serotype O:19. IgM anti-GM1 antibodies were detected by ELISA in 11 patients (45.8%) with MMN and in only one subject (4%) from the control group. Western blots showed positive reactivity of sera from 6 patients (25%) with MMN to several Gal(  β  1–3)GalNAc-bearing glycoproteins from human peripheral nerve and from  Cj  O:19 isolates. Sera from three patients (12.5%) with MMN showed positively reactive bands with similar electrophoretic mobility in all isolates (60–62 kDa, 48–51 kDa, 42 kDa, and 38 kDa). All six patients showed positive reactivity to 48–52 kDa protein isolated from human peripheral nerve. Increased titer of IgG antibodies to 60–62 kDa protein isolated from  Cj  O:19 associated with Guillain-Barré syndrome was detected in three patients, and their serum showed also IgG positive reactivity to peripheral nerve antigen with the same electrophoretic mobility. One of these patients had a previous history of  Cj  infection which suggests the possibility that  Cj  may be also involved in the pathogenesis of MMN.

Antibodies to Glycoproteins Shared by Human Peripheral Nerve andCampylobacter jejuniin Patients with Multifocal Motor Neuropathy