Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety | Zendy

Basavapat. Prasanna Kumar | Zendy; K. N. Mohana | Zendy; L. Mallesha | Zendy; Kikkeri P. Harish | Zendy

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Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety

Author(s) -

Basavapat. Prasanna Kumar,

K. N. Mohana,

L. Mallesha,

Kikkeri P. Harish

Publication year - 2013

Publication title -

international journal of medicinal chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-2069

pISSN - 2090-2077

DOI - 10.1155/2013/725673

Subject(s) - moiety , antimicrobial , chemistry , antifungal , in vitro , oxadiazole , proton nmr , mass spectrum , stereochemistry , medicinal chemistry , organic chemistry , combinatorial chemistry , microbiology and biotechnology , biochemistry , biology , ion

A series of new 1,3,4-oxadiazole derivatives, 4(a–h) , containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, 1 H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that compounds 4c , 4f , and 4g showed significant activity against tested strains.

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