Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats | Zendy

Jiasheng Wu | Zendy; Rong Shi | Zendy; Jie Zhong | Zendy; Xiong Lu | Zendy; BingLiang Ma | Zendy; Tianming Wang | Zendy; Bin Zan | Zendy; Yueming Ma | Zendy; Nengneng Cheng | Zendy; Furong Qiu | Zendy

Open Access

Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats

Author(s) -

Jiasheng Wu,

Rong Shi,

Jie Zhong,

Xiong Lu,

BingLiang Ma,

Tianming Wang,

Bin Zan,

Yueming Ma,

Nengneng Cheng,

Furong Qiu

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/715671

Subject(s) - glycation , diabetic nephropathy , downregulation and upregulation , advanced glycation end product , inflammation , pharmacology , diabetes mellitus , chemistry , albuminuria , medicine , endocrinology , biochemistry , gene

In Chinese medicine, Xiexin decoction (XXD) has been used for the clinical treatment of diabetes for at least 1700 years. The present study was conducted to investigate the effective ingredients of XXD and their molecular mechanisms of antidiabetic nephropathy in rats. Rats with diabetes induced by high-fat diet and streptozotocin were treated with XXD extract for 12 weeks. XXD significantly improved the glucolipid metabolism disorder, attenuated albuminuria and renal pathological changes, reduced renal advanced glycation end-products, inhibited receptor for advanced glycation end-product and inflammation factors expression, suppressed renal nuclear factor- κ B pathway activity, and downregulated renal transforming growth factor- β 1. The concentrations of multiple components in plasma from XXD were determined by liquid chromatography and tandem mass spectrometry. Pharmacokinetic/pharmacodynamic analysis using partial least square regression revealed that 8 ingredients of XXD were responsible for renal protective effects via actions on multiple molecular targets. Our study suggests that the renal protective role of XXD with multiple effective ingredients involves inhibition of inflammation through downregulation of the nuclear factor- κ B pathway, reducing renal advanced glycation end-products and receptor for advanced glycation end-product in diabetic rats.

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