Open AccessAnti-Inflammatory Effects ofHyptis albidaChloroform Extract on Lipopolysaccharide-Stimulated Peritoneal Macrophages
Author(s) -
Elizabeth Sánchez Miranda,
Julia Pérez Ramos,
Cristina Fresán Orozco,
Miguel Ángel Zavala-Sánchez,
Salud Pérez Gutiérrez
Publication year - 2013
Publication title -
isrn pharmacology
Language(s) - English
Resource type - Journals
eISSN - 2090-5173
pISSN - 2090-5165
DOI - 10.1155/2013/713060
Subject(s) - lipopolysaccharide , nitric oxide , tumor necrosis factor alpha , nitric oxide synthase , chloroform , chemistry , anti inflammatory , pharmacology , cyclooxygenase , microbiology and biotechnology , immunology , medicine , biology , biochemistry , enzyme , chromatography , organic chemistry
We examined the effects of a chloroform extract of Hyptis albida (CHA) on inflammatory responses in mouse lipopolysaccharide (LPS) induced peritoneal macrophages. Our findings indicate that CHA inhibits LPS-induced production of tumor necrosis factor (TNF- α ) and interleukin-6 (IL-6). During the process, levels of cyclooxygenase-2 (COX-2), nitric oxide synthase (iNOS), and nitric oxide (NO) increased in the mouse peritoneal macrophages; however, the extract suppressed them significantly. These results provide novel insights into the anti-inflammatory actions of CHA and support its potential use in the treatment of inflammatory diseases.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom