The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits | Zendy

Daiwei Zhou | Zendy; Bingbing Liu | Zendy; Xiaoshan Xiao | Zendy; Peng Dai | Zendy; Songmei Ma | Zendy; Weihua Huang | Zendy

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The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits

Author(s) -

Daiwei Zhou,

Bingbing Liu,

Xiaoshan Xiao,

Peng Dai,

Songmei Ma,

Weihua Huang

Publication year - 2013

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2013/692302

Subject(s) - lipid peroxidation , spinal cord , ischemia , reperfusion injury , spinal cord injury , hindlimb , pharmacology , medicine , apoptosis , anesthesia , chemistry , oxidative stress , biochemistry , psychiatry

Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and plasma levels of lipid peroxidation reactioin and neuronal morphologic changes. SCIRI remarkably affected the functional activities of the hind limbs and activated lipid peroxidation reaction. SY could attenuate apoptosis and SCIRI by enhancing Bcl-2 expression and inhibiting Bax and caspase-3 activation.

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