Synthesis and Bioevaluation of Thieno[2,3‐d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors | Zendy

Huangyong Li | Zendy; Changshui Chen | Zendy; ShengZhen Xu | Zendy; Xiufang Cao | Zendy

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Synthesis and Bioevaluation of Thieno[2,3‐d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors

Author(s) -

Huangyong Li,

Changshui Chen,

ShengZhen Xu,

Xiufang Cao

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/692074

Subject(s) - chemistry , alkylation , mtt assay , tumor cells , inhibitory postsynaptic potential , combinatorial chemistry , cell growth , in vitro , cell culture , stereochemistry , positive control , biochemistry , cancer research , catalysis , traditional medicine , medicine , genetics , neuroscience , biology

A series of novel cycloalkylthieno[2,3-d]pyrimidinone derivatives have been conveniently synthesized via three steps including G-3CR, heterocyclization, and alkylation reactions as a part of our ongoing search for new bioactive molecules. The newly synthesized compounds were evaluated for their potential tumor cell growth inhibitory activity by standard MTT assay. The preliminary results show that compound 6b exhibited better inhibitory activities against HepG2, MCF-7, and BCG-823 cell lines compared to the control

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