Open AccessSynthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction
Author(s) -
Shuhei Narita,
Tetsuhiro Ogura,
Toyonobu Usuki
Publication year - 2012
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.436
H-Index - 50
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2013/686242
Subject(s) - chemistry , component (thermodynamics) , pigment , combinatorial chemistry , organic chemistry , thermodynamics , physics
Magnolignan, 2,2′-dihydroxy-5,5′-dipropyl-biphenyl (1), is a down-regulator of melanin synthesis that inhibits the maturation of tyrosinase. In this study, a concise total synthesis of 1 was achieved in five steps with 50% overall yield starting from commercially available trans-anethole (2) via a Suzuki-Miyaura reaction.
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