Psoriasin: A Novel Marker Linked Obesity with Psoriasis | Zendy

Ragaa H. M. Salama | Zendy; Hani A. AlShobaili | Zendy; Ahmad A. Al Robaee | Zendy; Abdullateef A. Alzolibani | Zendy

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Psoriasin: A Novel Marker Linked Obesity with Psoriasis

Author(s) -

Ragaa H. M. Salama,

Hani A. AlShobaili,

Ahmad A. Al Robaee,

Abdullateef A. Alzolibani

Publication year - 2013

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2013/659864

Subject(s) - psoriasis , medicine , psoriasis area and severity index , psoriatic arthritis , obesity , pathogenesis , dermatology , biomarker , body mass index , interleukin 17 , immunology , gastroenterology , inflammation , biochemistry , chemistry

To evaluate the role of psoriasin, koebnerisin, interleukn (IL)-12 and IL-23 in the pathogenesis of psoriasis and their relations to Psoriasis Area Severity Index (PASI) and obesity. Thirty patients had chronic plaque psoriasis and 30 healthy subjects matched in age and sex were enrolled in this study. Serum from all subjects were used for determination of psoriasin, koebnerisin, IL-12 and IL-23 by ELISA kits. IL-23 and psoriasin were significantly higher in skin psoriasis compared to controls and psoriatic arthritis (PsA). There was a correlation between psoriasin and both PASI and obesity. On the other hand, IL-12 was significantly increased in PsA compared to skin psoriasis ( p = 0.000) and controls. Its sensitivity and specificity were 87%, 93%; respectively. To our knowledge, psoriasin is the first biomarker confirm the link between obesity and psoriasis. The risk of developing psoriasis is directly related to higher BMI.

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