Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions | Zendy

Sónia PérezRentero | Zendy; Álvaro Somoza | Zendy; Santiago Grijalvo | Zendy; Jiří Janoušek | Zendy; Martin Bělohradský | Zendy; Irena G. Stará̈ | Zendy; Ivo Starý | Zendy; Ramón Eritja | Zendy

Open Access

Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions

Author(s) -

Sónia PérezRentero,

Álvaro Somoza,

Santiago Grijalvo,

Jiří Janoušek,

Martin Bělohradský,

Irena G. Stará̈,

Ivo Starý,

Ramón Eritja

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/650610

Subject(s) - oligonucleotide , chemistry , tetrathiafulvalene , pyrene , conjugate , combinatorial chemistry , rna , molecule , nucleic acid , stereochemistry , biochemistry , dna , organic chemistry , gene , mathematical analysis , mathematics

Oligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3′ or 5′ ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized with oligonucleotides. Finally, TTF-oligoribonucleotides have been synthesized to produce siRNA duplexes carrying TTF units. The presence of the TTF molecule is compatible with the RNA interference mechanism for gene inhibition

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