Protective Effect of Theaflavin on Erythrocytes Subjected toIn VitroOxidative Stress | Zendy

Mahejabeen Fatima | Zendy; Rajesh K. Kesharwani | Zendy; Krishna Misra | Zendy; Syed Ibrahim Rizvi | Zendy

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Protective Effect of Theaflavin on Erythrocytes Subjected toIn VitroOxidative Stress

Author(s) -

Mahejabeen Fatima,

Rajesh K. Kesharwani,

Krishna Misra,

Syed Ibrahim Rizvi

Publication year - 2013

Publication title -

biochemistry research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.631

H-Index - 36

eISSN - 2090-2255

pISSN - 2090-2247

DOI - 10.1155/2013/649759

Subject(s) - theaflavin , oxidative stress , malondialdehyde , antioxidant , glutathione , black tea , in vitro , pharmacology , intracellular , medicine , oxidative phosphorylation , biochemistry , chemistry , food science , enzyme , polyphenol

Antioxidant and free radical scavenging effect of black tea theaflavins has been shown in many epidemiological studies. In the present work we report the protective mechanism of tea theaflavins on biomarkers of oxidative stress, which are elevated during stress conditions. We hereby report the in vitro effect of theaflavins on erythrocyte malondialdehyde (MDA), intracellular reduced glutathione (GSH), and plasma membrane redox system (PMRS) of rats. The effect of theaflavin on PMRS has also been validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). We report that theaflavins show significant protection to erythrocyte against oxidative stress induced by tert -butyl hydroperoxide (t-BHP). The findings suggest a possible protective role of theaflavins as antioxidant.

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