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Aim.  This study investigated the effect of  Dodonaea viscosa  var.  angustifolia  (DVA) on the virulence properties of cariogenic  Streptococcus mutans  and  Porphyromonas gingivalis  implicated in periodontal diseases.  Methods. S. mutans  was cultured in tryptone broth containing a crude leaf extract of DVA for 16 hours, and the pH was measured after 10, 12, 14, and 16 h. Biofilms of  S. mutans  were grown on glass slides for 48 hours and exposed to plant extract for 30 minutes; the adherent cells were reincubated and the pH was measured at various time intervals. Minimum bactericidal concentration of the extracts against the four periodontal pathogens was determined. The effect of the subinhibitory concentration of plant extract on the production of proteinases by  P. gingivalis  was also evaluated.  Results.  DVA had no effect on acid production by  S. mutans  biofilms; however, it significantly inhibited acid production in planktonic cells. Periodontal pathogens were completely eliminated at low concentrations ranging from 0.09 to 0.02 mg/mL of crude plant extracts. At subinhibitory concentrations, DVA significantly reduced Arg-gingipain (24%) and Lys-gingipain (53%) production by  P. gingivalis  ( P  ≤ 0.01).  Conclusions.  These results suggest that DVA has the potential to be used to control oral infections including dental caries and periodontal diseases.

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Inhibitory Effect ofDodonaea viscosavar.angustifoliaon the Virulence Properties of the Oral PathogensStreptococcus mutansandPorphyromonas gingivalis