Synthesis and Evaluation of Substituted 4,4a-Dihydro-3H,10H-pyrano[4,3-b][1]benzopyran-10-one as Antimicrobial Agent | Zendy

Amanpreet Kaur | Zendy; Vishal Sharma | Zendy; Abhishek Budhiraja | Zendy; Harpreet Kaur | Zendy; Vivek K. Gupta | Zendy; Rajni Kant | Zendy; Mohan Paul S. Ishar | Zendy

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Synthesis and Evaluation of Substituted 4,4a-Dihydro-3H,10H-pyrano[4,3-b][1]benzopyran-10-one as Antimicrobial Agent

Author(s) -

Amanpreet Kaur,

Vishal Sharma,

Abhishek Budhiraja,

Harpreet Kaur,

Vivek K. Gupta,

Rajni Kant,

Mohan Paul S. Ishar

Publication year - 2013

Publication title -

isrn medicinal chemistry

Language(s) - English

Resource type - Journals

ISSN - 2314-629X

DOI - 10.1155/2013/619535

Subject(s) - antimicrobial , chemistry , enol , staphylococcus aureus , benzopyran , inhibitory postsynaptic potential , minimum inhibitory concentration , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , bacteria , biology , catalysis , neuroscience , genetics

A series of pyrano[4,3-b][1]benzopyranones (7a–t) were synthesized through hetero-Diels-Alder reaction of substituted 3-formylchromones (5) with enol ethers (6), characterized by IR, 1H NMR, 13C NMR, and mass spectral techniques. All the compounds were evaluated for antimicrobial activity against various bacterial and fungal strains, found to possess significant inhibitory potential, particularly, compounds bearing electron withdrawing group -fluoro such as 7i and 7h. Compounds were also tested and displayed a significant inhibitory potential against methicillin-resistant Staphylococcus aureus (MRSA).

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