Antimicrobial Activity ofLippiaSpecies from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents | Zendy

Cristiana da Purificação Pinto | Zendy; Velize Dias Rodrigues | Zendy; Fernanda da Purificação Pinto | Zendy; Renata da Purificação Pinto | Zendy; Ana Paula Trovatti Uetanabaro | Zendy; Carla Santos Ribeiro Pinheiro | Zendy; Suzana Ferreira Magalhães Gadea | Zendy; Tânia Regina dos Santos Silva | Zendy; María Angélica | Zendy

Open Access

Antimicrobial Activity ofLippiaSpecies from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents

Author(s) -

Cristiana da Purificação Pinto,

Velize Dias Rodrigues,

Fernanda da Purificação Pinto,

Renata da Purificação Pinto,

Ana Paula Trovatti Uetanabaro,

Carla Santos Ribeiro Pinheiro,

Suzana Ferreira Magalhães Gadea,

Tânia Regina dos Santos Silva,

María Angélica

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/614501

Subject(s) - lippia , antimicrobial , traditional medicine , broth microdilution , biology , antiseptic , microbiology and biotechnology , ethyl acetate , agar , medicinal plants , bacteria , chemistry , minimum inhibitory concentration , medicine , botany , essential oil , biochemistry , genetics , organic chemistry

Lippia origanoides Kunth, Lippia alnifolia Schauer, and Lippia thymoides Martius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine. L. origanoides leaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts; this activity was also confirmed by the MIC evaluation. The fractionation of L. origanoides crude extracts improved the activity in spectrum and intensity. The results obtained in this study indicate that L. origanoides may be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs.

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