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Aim . The aim of this study was to identify the presence of  H. pylori  in biopsy specimens from symptomatic patients by PCR. In addition, the rate of  cagA ,  vacA ,  iceA1 , and  iceA2  virulence genes was determined.  Materials and Methods . One hundred antral gastric biopsy specimens were collected during endoscopy from patients suffering from gastroduodenal symptoms. The samples were collected by the gastroenterologists in their own clinics in Ramallah, Palestine. DNA was extracted from the biopsies and subsequently used for PCR identification of  H. pylori  and the virulence genes using specific primers.  Results . The rate of positive  H. pylori  in the collected biopsies was 44%. The rates of the virulence genes in this sample:  cagA ,  vacA ,  iceA1 , and  iceA2  were 65.9%, 40.9%, 63.6%, and 84.1%, respectively.  Conclusion . The  iceA2  gene was the most frequent in this study. Much research is necessary to determine the presence of an association of this gene with gastric pathology. Variation in the rates of the  iceA  gene in different countries is a strong indication of its geographical distribution. This study would provide important information regarding the prevalence of virulence genes ( vacA ,  cagA ,  iceA1 , and  iceA2 ) in  H. pylori  strains in the sample tested in this country.

Determination of Helicobacter pylori Virulence Genes in Gastric Biopsies by PCR