Effect of Delay on Selection Dynamics in Long-Term Sphere Culture of Cancer Stem Cells | Zendy

Peng Tang | Zendy; Aijun Fan | Zendy; Jianquan Li | Zendy; Jun Jiang | Zendy; Kaifa Wang | Zendy

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Effect of Delay on Selection Dynamics in Long-Term Sphere Culture of Cancer Stem Cells

Author(s) -

Peng Tang,

Aijun Fan,

Jianquan Li,

Jun Jiang,

Kaifa Wang

Publication year - 2013

Publication title -

discrete dynamics in nature and society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.264

H-Index - 39

eISSN - 1607-887X

pISSN - 1026-0226

DOI - 10.1155/2013/606250

Subject(s) - selection (genetic algorithm) , term (time) , dynamics (music) , biological system , computer science , mathematics , biology , statistical physics , physics , artificial intelligence , quantum mechanics , acoustics

To quantitatively study the effect of delay on selection dynamics in long-term sphere culture of cancer stem cells (CSCs), a selection dynamic model with time delay is proposed. Theoretical results show that the ubiquitous time delay in cell proliferation may be one of the important factors to induce fluctuation, and numerical simulations indicate that the proposed selection dynamical model with time delay can provide a better fitting effect for the experiment of a long-term sphere culture of CSCs. Thus, it is valuable to consider the delay effect in the future study on the dynamics of nongenetic heterogeneity of clonal cell populations

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