English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background . Ivabradine is an If ion current inhibitor that has proved to reduce mortality in patients with systolic heart failure by slowing heart rate without decreasing myocardial contractility. Photoplethysmography is a simple, low-cost optical technique that can evaluate vascular function and detect changes in blood flow, pulse, and swelling of tissular microvascular space.  Objective . To evaluate the effect of ivabradine on endothelial function by photoplethysmography in diastolic and right heart failure patients.  Methodology . 15 patients were included (mean age of 78.1 ± 9.2 years) with optimally treated diastolic and right heart failure. They underwent photoplethysmography before and after induced ischemia to evaluate the wave blood flow on the finger, using the maximum amplitude time/total time (MAT/TT) index. Two measurements were made before and after oral Ivabradine (mean 12.5 mg a day during 6 months of followup).  Results . In the study group, the MAT/TT index was 29.1 ± 2.2 versus 24.3 ± 3.2 ( P  = 0.05) in basal recording and 30.4 ± 2.1 versus 23.3 ± 2.9 ( P  = 0.002), before versus after ischemia and before versus after Ivabradine intervention, respectively.  Conclusions . Ivabradine administration improves endothelial function (shear stress) in diastolic and right heart failure patients.

Effect of Ivabradine on Endothelial Function in Diastolic and Right Heart Failure Patients