Methadone-Induced Toxic Brain Damage | Zendy

Jérôme Corré | Zendy; Jérôme Pillot | Zendy; Gilles Hilbert | Zendy

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Methadone-Induced Toxic Brain Damage

Author(s) -

Jérôme Corré,

Jérôme Pillot,

Gilles Hilbert

Publication year - 2013

Publication title -

case reports in radiology

Language(s) - English

Resource type - Journals

eISSN - 2090-6862

pISSN - 2090-6870

DOI - 10.1155/2013/602981

Subject(s) - basal ganglia , medicine , methadone , hyperintensity , fluid attenuated inversion recovery , cerebellum , anesthesia , cerebellar hemisphere , neuroscience , magnetic resonance imaging , psychology , central nervous system , radiology

A 29-year-old man presented with comatose after methadone intoxication. Cerebral tomography only showed cortico-subcortical hypodense signal in the right cerebellar hemisphere. Brain MRI showed a rare imaging of FLAIR and DWI hyperintensities in the two cerebellar hemispheres as well as basal ganglia (globi pallidi), compatible with methadone overdose. To our knowledge this is the first reported case of both cerebellar and basal ganglia involvement in methadone overdose.

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