Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect | Zendy

Chunying Cui | Zendy; Yuji Wang | Zendy; Yaonan Wang | Zendy; Ming Zhao | Zendy; Shiqi Peng | Zendy

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Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect

Author(s) -

Chunying Cui,

Yuji Wang,

Yaonan Wang,

Ming Zhao,

Shiqi Peng

Publication year - 2013

Publication title -

journal of analytical methods in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.407

H-Index - 25

eISSN - 2090-8865

pISSN - 2090-8873

DOI - 10.1155/2013/602091

Subject(s) - hela , apoptosis , cyclin dependent kinase , cell cycle , microbiology and biotechnology , kinase , cdk inhibitor , programmed cell death , cell cycle progression , cyclin , biology , chemistry , cell , cancer research , biochemistry

Alsterpaullone, a small molecule cyclin-dependent kinase (CDK) inhibitor, regulates the cell cycle progression. Beyond death-inducing properties, we identified the effect of alsterpaullone on cycle procedure and apoptosis of HeLa cell. It was found that alsterpaullone inhibited HeLa cells in a time-dependent (0–72 h) and dose-dependent (0–30 μ M) manner. In the presence of alsterpaullone, HeLa cells were arrested in G 2 /M prior to undergoing apoptosis via a mechanism that is involved in the regulation of various antiapoptotic genes, DNA-repair, transcription, and cell cycle progression. Compared to controls, alsterpaullone effectively prevented HeLa cells from entering S-phase. These potential therapeutic efficacies could be correlated with the activation of caspase-3.

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