Long-Term Use of Probiotic-Containing Yogurts Is a Safe Way to PreventHelicobacter pylori: Based on a Mongolian Gerbil's Model

Background . The suppression of Helicobacter pylori ( H. pylori ) decreases H. pylori -related diseases. The probiotics have an inhibitory effect on H. pylori . Aim . We investigated the effects of long-term use of yogurt on H. pylori based on Mongolian gerbils' model. Materials and Methods . Yogurt (containing a supplement of Lactobacillus acidophilus, Bifidobacterium lactis, etc. ) was used. Forty-six gerbils were divided into five groups. All groups were inoculated with H. pylori for 5 to 8 weeks. The yogurt was given as follows: Group (Gr.) A: from 1st to 4th week; Gr. B from 5th to 8th week; Gr. C: from 17th week to sacrifice; Gr. D: from 5th week to sacrifice. Gerbils were sacrificed on the 52nd week. Histology was evaluated according to the Sydney system. Results . The positive rates of H. pylori were 60% (Gr. A), 75% (Gr. B), 67% (Gr. C), 44% (Gr. D), and 100% (Gr. E). Gr. D showed lower inflammatory score. Only Gr. E (60%) had intestinal metaplasia. Gr. D showed higher IL-10 and lower TNF- α expression than Gr. E. Conclusion. Long-term intake of yogurt could decrease H. pylori infection. The long-term use of yogurt would be an alternative strategy to manage H. pylori infection.