Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats | Zendy

A. L. Zagayko | Zendy; Ganna Kravchenko | Zendy; Oksana Krasilnikova | Zendy; Yuri O. Ogai | Zendy

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Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

Author(s) -

A. L. Zagayko,

Ganna Kravchenko,

Oksana Krasilnikova,

Yuri O. Ogai

Publication year - 2013

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2013/593761

Subject(s) - cholesterylester transfer protein , medicine , paraoxonase , endocrinology , cholesterol , chemistry , obesity , apolipoprotein b , polyphenol , composition (language) , acyltransferase , apolipoprotein e , enzyme , lipoprotein , biochemistry , oxidative stress , antioxidant , linguistics , philosophy , disease

HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG) levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON) and lecithin:cholesterol acyltransferase (LCAT) activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP) activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.

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