English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Matrine (Mat) is a major alkaloid extracted from  Sophora flavescens  Ait, an herb which is used in the traditional Chinese medicine for treatment of inflammation, cancer, and other diseases. The present study examined the impact of Mat on the CCl 4 -induced hepatic infiltration of Gr1 hi  monocytes to explore the possible mechanisms underlying its anti-inflammatory and antifibrotic effects. The results indicated that Mat protected mice from acute liver injury induced by single intraperitoneal injection of CCl 4  and attenuated liver fibrosis induced by repeated CCl 4  injection. Meanwhile, the infiltrations of Gr1 hi  monocytes in both acute and chronic injured livers were all inhibited, and the enhanced hepatic expression of MCP-1 was suppressed. Cellular experiments demonstrated that Mat directly inhibited MCP-1 production in both nonparenchymal cells and hepatic stellate cells derived from CCl 4 -injured livers. Transwell chemotaxis assays showed that Mat significantly inhibited the chemotactic activity of MCP-1. These results suggest that the anti-inflammatory and antifibrotic effects of Mat could be contributed, at least in part, to its prevention of Gr1 hi  monocyte infiltration into the injured livers and inhibition of MCP-1 production and activity. These findings extend our understanding of the mechanisms underlying the anti-inflammatory and antifibrotic effects of Mat.

evidence-based complementary and alternative medicine

Matrine Inhibits Infiltration of the Inflammatory<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mtext>Gr</mml:mtext><mml:msup><mml:mtext>1</mml:mtext><mml:mrow><mml:mtext>hi</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>Monocyte Subset in Injured Mouse Liver through Inhibition of Monocyte Chemoattractant Protein-1

Matrine Inhibits Infiltration of the InflammatoryGr1hiMonocyte Subset in Injured Mouse Liver through Inhibition of Monocyte Chemoattractant Protein-1