The Liver X Receptor in Correlation with Other Nuclear Receptors in Spontaneous and Recurrent Abortions | Zendy

Julia Knabl | Zendy; Aurelia Pestka | Zendy; Rebecca Hüttenbrenner | Zendy; Torsten Plösch | Zendy; Regina Ensenauer | Zendy; Lena Welbergen | Zendy; Stefan Hutter | Zendy; Maria Günthner-Biller | Zendy; Udo Jeschke | Zendy

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The Liver X Receptor in Correlation with Other Nuclear Receptors in Spontaneous and Recurrent Abortions

Author(s) -

Julia Knabl,

Aurelia Pestka,

Rebecca Hüttenbrenner,

Torsten Plösch,

Regina Ensenauer,

Lena Welbergen,

Stefan Hutter,

Maria Günthner-Biller,

Udo Jeschke

Publication year - 2013

Publication title -

ppar research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 49

eISSN - 1687-4765

pISSN - 1687-4757

DOI - 10.1155/2013/575604

Subject(s) - liver x receptor , syncytiotrophoblast , miscarriage , decidua , recurrent miscarriage , downregulation and upregulation , trophoblast , retinoid x receptor , endocrinology , nuclear receptor , medicine , abortion , placentation , fetus , peroxisome proliferator activated receptor , placenta , biology , andrology , pregnancy , receptor , biochemistry , genetics , transcription factor , gene

The liver X receptors (LXRs) have been shown to be crucially involved in maternal-fetal cholesterol transport and placentation. The aim of this study was to investigate the expression pattern and frequency of LXR under normal physiological circumstances and in spontaneous abortion and/or recurrent miscarriage. A total of 29 (12 physiologic pregnancies/10 spontaneous abortions/7 recurrent miscarriages) human pregnancies in first trimester were analysed for LXR expression. Expression changes were evaluated by immunohistochemistry for receptor and quantitative RT-PCR (TaqMan) was performed to determine the level of LXR mRNA expression. We also stained for RXR α and PPAR γ as possible heterodimers of LXR. LXR expression was downregulated in the syncytiotrophoblast of spontaneous abortion placentas compared to normal pregnancy. In recurrent miscarriage there was a trend for a downregulation. Decidua showed an even stronger downregulation in both groups. In the syncytiotrophoblast we found a positive correlation for the combination of LXR/PPAR γ in abortions and a negative correlation for LXR/RXR α . In addition, double-immunofluorescence staining showed that LXR as well as RXR α and PPAR γ are expressed by the extravillous trophoblast. Finally, RXR α and LXR showed coexpression in the same extravillous trophoblast cells. To conclude, our data show that LXR expression is decreased in miscarriage.

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