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The investigation of ultradiluted (homeopathic) drugs is extremely interesting and challenging, and from that point of view this study shows novelty. A study of in vivo changes in heart rate of the Indian  Bufo melanostictus  caused by commercially available serially ultra-diluted and agitated extract of  Digitalis purpurea  has been tried in order to understand their pharmacological role. RR interval (of ECG) was compared after intraperitoneal administration of serially diluted and agitated  Digitalis purpurea  extract, diluent rectified spirit, and Digoxin in anesthetized animals. The study revealed statistically significant changes in the heart rate after application of these drugs except in case of Digoxin and the 200th serial dilution of  Digitalis purpurea . The duration of RR intervals after application of the drugs was corroborative of the effect of Digoxin and  Digitalis purpurea  extract up to 30th dilution. Emission spectra were obtained for the experimental ultra-diluted  Digitalis purpurea  extract and Digoxin to identify and characterize them. The observed RR pattern and emission spectra show an association. The quality assessment of the commercial ultra-diluted organic drugs obtained from natural products may be initiated by monitoring in vivo studies on animal models.

journal of pharmaceutics

Quality Assessment of Serially Ultradiluted and Agitated Drug <i>Digitalis purpurea</i> by Emission Spectroscopy and Clinical Analysis of Its Effect on the Heart Rate of Indian <i>Bufo melanostictus</i>

Quality Assessment of Serially Ultradiluted and Agitated Drug Digitalis purpurea by Emission Spectroscopy and Clinical Analysis of Its Effect on the Heart Rate of Indian Bufo melanostictus