Synthesis, Characterization, and Biological and Cytotoxic Studies of Copper(II), Nickel(II), and Zinc(II) Binary Complexes of 3-Amino-5-methyl Isoxazole Schiff Base | Zendy

K. S. A. Kumar | Zendy; Vijay Kumar Chityala | Zendy; N. J. P. Subhashini | Zendy; Y. Prashanthi | Zendy; Shivaraj Shivaraj | Zendy

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Synthesis, Characterization, and Biological and Cytotoxic Studies of Copper(II), Nickel(II), and Zinc(II) Binary Complexes of 3-Amino-5-methyl Isoxazole Schiff Base

Author(s) -

K. S. A. Kumar,

Vijay Kumar Chityala,

N. J. P. Subhashini,

Y. Prashanthi,

Shivaraj Shivaraj

Publication year - 2013

Publication title -

isrn inorganic chemistry

Language(s) - English

Resource type - Journals

ISSN - 2314-470X

DOI - 10.1155/2013/562082

Subject(s) - schiff base , chemistry , octahedral molecular geometry , zinc , copper , metal , nickel , metal ions in aqueous solution , cadmium , cobalt , crystallography , stereochemistry , nuclear chemistry , inorganic chemistry , organic chemistry

Binary complexes of Cu(II), Ni(II), and Zn(II) ions have been synthesized by reacting metal salts with a Schiff base, 2-((E)-(5-methylisoxazol-3-ylimino)methyl)-4-methoxyphenol (MIIMMP) in an alcoholic medium. All the metal complexes and schiff base have been characterized by using elemental analysis, IR, UV-VIS, 1 H-NMR, 13 C-NMR, Mass, ESR spectral data, magnetic moments, TG, and DTA studies. Based on the analytical, spectral data and molecular modeling studies, Ni(II) and Zn(II) metal complexes have octahedral geometry, whereas Cu(II) complex has tetragonal geometry. The antimicrobial and cytotoxic activities of the Schiff base and its metal complexes were studied on bacteria, fungi, and human cervical carcinoma cells (HeLa).

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