Inclusion-Body Myositis Associated with Alzheimer’s Disease | Zendy

Danijela Levacic | Zendy; Leema Reddy Peddareddygari | Zendy; David Nochlin | Zendy; Leroy R. Sharer | Zendy; Raji P. Grewal | Zendy

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Inclusion-Body Myositis Associated with Alzheimer’s Disease

Author(s) -

Danijela Levacic,

Leema Reddy Peddareddygari,

David Nochlin,

Leroy R. Sharer,

Raji P. Grewal

Publication year - 2013

Publication title -

case reports in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.2

H-Index - 20

eISSN - 1687-9627

pISSN - 1687-9635

DOI - 10.1155/2013/536231

Subject(s) - inclusion body myositis , medicine , myopathy , etiology , disease , myositis , pathology , inclusion bodies , muscle disease , vacuole , amyloid (mycology) , inflammatory myopathy , weakness , anatomy , biology , genetics , gene , escherichia coli , cytoplasm

Sporadic inclusion-body myositis (s-IBM) is a myopathy that is characterized by progressive weakness and muscle pathology demonstrating inflammation and rimmed vacuoles. In addition, similar to the pathology observed in the brains of patients with Alzheimer's disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. These shared pathologic features have prompted hypotheses suggesting a shared etiology of these two conditions. We report a case of a 73-year-old woman initially diagnosed with s-IBM who later developed Alzheimer's disease.

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