Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful? | Zendy

Parvaz Madadi | Zendy; Johanna Sistonen | Zendy; Gregory L. Silverman | Zendy; Rebecca Gladdy | Zendy; Colin J.D. Ross | Zendy; Bruce Carleton | Zendy; José C. A. Carvalho | Zendy; Michael R. Hayden | Zendy; Gideon Koren | Zendy

Open Access

Life-Threatening Adverse Events Following Therapeutic Opioid Administration in Adults: Is Pharmacogenetic Analysis Useful?

Author(s) -

Parvaz Madadi,

Johanna Sistonen,

Gregory L. Silverman,

Rebecca Gladdy,

Colin J.D. Ross,

Bruce Carleton,

José C. A. Carvalho,

Michael R. Hayden,

Gideon Koren

Publication year - 2013

Publication title -

pain research and management

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.702

H-Index - 56

eISSN - 1918-1523

pISSN - 1203-6765

DOI - 10.1155/2013/518012

Subject(s) - hydromorphone , pharmacogenetics , medicine , opioid , alfentanil , morphine , cyp2d6 , context (archaeology) , adverse effect , methadone , pharmacology , anesthesia , codeine , genotype , fentanyl , biology , paleontology , biochemistry , receptor , cytochrome p450 , metabolism , gene

Systemic approaches are needed to understand how variations in the genes associated with opioid pharmacokinetics and response can be used to predict patient outcome. The application of pharmacogenetic analysis to two cases of life-threatening opioid-induced respiratory depression is presented. The usefulness of genotyping in the context of these cases is discussed.

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