Synthesis and Characterization of Process‐Related Impurities of Antihypertensive Drug Olmesartan Medoxomil | Zendy

G.T. Venkanna | Zendy; G. Madhusudhan | Zendy; K. Mukkanti | Zendy; Ask Sankar | Zendy; Y. Sampath Kumar | Zendy; G. Venakata Narayana | Zendy

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Synthesis and Characterization of Process‐Related Impurities of Antihypertensive Drug Olmesartan Medoxomil

Author(s) -

G.T. Venkanna,

G. Madhusudhan,

K. Mukkanti,

Ask Sankar,

Y. Sampath Kumar,

G. Venakata Narayana

Publication year - 2012

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/516459

Subject(s) - olmesartan , chemistry , impurity , antihypertensive drug , drug , characterization (materials science) , pharmacology , process (computing) , chromatography , medicine , nanotechnology , organic chemistry , blood pressure , materials science , computer science , operating system

Olmesartan medoxomil (1) is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension. During the process development of olmesartan medoxomil, three process-related impurities were observed along with the final API. These impurities were identified as isopropyl olmesartan (12), dimedoxomil olmesartan (19), dibiphenyl olmesartan (17). The present work describes the synthesis and characterization of all these three impurities

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