The Potential of Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition | Zendy

Karel D. Klika | Zendy

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The Potential of Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition

Author(s) -

Karel D. Klika

Publication year - 2013

Publication title -

isrn organic chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-5157

pISSN - 2090-5149

DOI - 10.1155/2013/515810

Subject(s) - isotopomers , deuterium , chemistry , drosophila melanogaster , acetophenone , olfaction , kinetic isotope effect , computational chemistry , stereochemistry , molecule , physics , biochemistry , organic chemistry , neuroscience , biology , quantum mechanics , gene , catalysis

The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of 13 C-labeled odorants. The application of 13 C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (Δ G ) for acetophenone and octan-1-ol, two odorants for which the 2 D (deuterium) isotopomers have previously been shown to be discernible from their respective 1 H (normal) counterparts by Drosophila melanogaster .

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