High Prevalence and Genotypic Diversity of the Human Papillomavirus in Amazonian Women, Brazil | Zendy

Danielle Albuquerque Pires Rocha | Zendy; Roberto Alexandre Alves Barbosa Filho | Zendy; Francisca Andrade de Queiroz | Zendy; Cristina Maria Borborema dos Santos | Zendy

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High Prevalence and Genotypic Diversity of the Human Papillomavirus in Amazonian Women, Brazil

Author(s) -

Danielle Albuquerque Pires Rocha,

Roberto Alexandre Alves Barbosa Filho,

Francisca Andrade de Queiroz,

Cristina Maria Borborema dos Santos

Publication year - 2013

Publication title -

infectious diseases in obstetrics and gynecology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.656

H-Index - 48

eISSN - 1098-0997

pISSN - 1064-7449

DOI - 10.1155/2013/514859

Subject(s) - ascus (bryozoa) , genotyping , genotype , cervical cancer , cytology , human papillomavirus , population , gynecology , polymerase chain reaction , amplicon , medicine , virology , cancer , biology , genetics , pathology , microbiology and biotechnology , environmental health , gene , ascospore , spore

The aim of this study was to determine the prevalence of human papillomavirus (HPV) in a women population living within the state of Amazonas, Brazil, and to determine the viral genotypes found. The study included 361 sexually active women over 18 years of age. We performed the Pap test and the molecular diagnosis for HPV DNA using polymerase chain reaction (PCR). The amplicons obtained were sequenced in automatic sequencer for genotyping. The presence of HPV DNA was found in 29.1% (105) of the women. Only 321 women presented satisfactory slides for cytological diagnosis, 97.9% (314) had normal cytology (negative for cancer), and 2.1% (7) had abnormal cytology (4 ASCUS, 1 LSIL, and 2 HSIL). The types more frequently found were HPV 16 (58.1%) and HPV 58 (20.0%). Additionally, we found more 13 types of HPV. Compared with previous studies in Brazil, our data confirmed a high prevalence and genotypic diversity of HPV in Brazilian women.

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