English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

To determine the biological activity of  Rhodiola rosea , the protein expression of iNOS and proinflammatory cytokines was measured after the activation of murine microglial BV2 cells by LPS under the exposure of constituents of  Rhodiola rosea : crude extract, rosin, rosarin, and salidroside (each 1–50   μ  g/mL). The LPS-induced expression of iNOS and cytokines in BV2 cells was suppressed by the constituents of  Rhodiola rosea  in a concentration-dependent manner. Also the expression of the proinflammatory factors iNOS, IL-1  β  , and TNF-  α   in the kidney and prefrontal cortex of brain in mice was suppressed by the oral administration of  Rhodiola rosea  crude extract (500 mg/kg). To determine the neuroprotective effect of constituents of  Rhodiola rosea , neuronal cells were activated by L-glutamate, and neurotoxicity was analyzed. The L-glutamate-induced neurotoxicity was suppressed by the treatment with rosin but not by rosarin. The level of phosphorylated MAPK, pJNK, and pp38 was increased by L-glutamate treatment but decreased by the treatment with rosin and salidroside. These results indicate that  Rhodiola rosea  may have therapeutic potential for the treatment of inflammation and neurodegenerative disease.

Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated fromRhodiola rosea