BRAFV600E-Negative Hairy Cell Leukaemia | Zendy

Stephen E. Langabeer | Zendy; David O’Brien | Zendy; Anthony M. McElligott | Zendy; Michelle Lavin | Zendy; Paul Browne | Zendy

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BRAFV600E-Negative Hairy Cell Leukaemia

Author(s) -

Stephen E. Langabeer,

David O’Brien,

Anthony M. McElligott,

Michelle Lavin,

Paul Browne

Publication year - 2013

Publication title -

case reports in hematology

Language(s) - English

Resource type - Journals

eISSN - 2090-6560

pISSN - 2090-6579

DOI - 10.1155/2013/513049

Subject(s) - hairy cell leukemia , medicine , leukemia , hairy cell , mutation , cancer research , pathology , cell , immunology , genetics , biology , gene

Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, and cytochemical profile in which the BRAF V600E was not detected. The diagnostic and therapeutic implications are discussed.

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