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Objective . The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors.  Methods . This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 ( n  = 57) group or the placebo group ( n  = 55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition.  Results . The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed ( P  = 0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group ( P  < 0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group.  Conclusion . Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.

Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults: A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial