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Objective . To determine whether initial biopsy performed by community or academic urologists affected rates of Gleason upgrading at a tertiary referral center. Gleason upgrading from biopsy to radical prostatectomy (RP) is an important event as treatment decisions are made based on the biopsy score.  Materials and Methods . We identified men undergoing RP for Gleason 3 + 3 or 3 + 4 disease at a tertiary care academic center. Biopsy performed in the community was centrally reviewed at the academic center. Multivariate logistic regression was used to determine factors associated with Gleason upgrading.  Results . We reviewed 1,348 men. There was no difference in upgrading whether the biopsy was performed at academic or community sites (OR 0.9, 95% CI 0.7–1.2). Increased risk of upgrading was seen in those with >1 positive core, older men, and those with higher PSAs. Secondary pattern 4 and larger prostate size were associated with a reduction in risk of upgrading. Compared to the smallest quartile of prostate size (<35 g), those in the highest quartile (>56 g) had a 49% reduction in risk of upgrading (OR 0.51, 95% CI 0.3–0.7).  Conclusion . There was no difference in upgrading between where the biopsy was performed and community and academic urologists.

Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices