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Objective . To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene,  p -cymene, and geranyl acetate in  in vivo  and  in vitro  experimental models.  Methods . Evaluation of the  in vitro  antioxidant activity of (+)-camphene,  p -cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice.  Results .  p -Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect  in vitro  at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and  p -cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied.  Conclusion . (+)-Camphene,  p -cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for  p -cymene and geranyl acetate.

Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene,p-Cymene, and Geranyl Acetate in Experimental Models