Ginsenoside Rb1 Reduces Isoproterenol-Induced Cardiomyocytes ApoptosisIn VitroandIn Vivo | Zendy

Xiufeng Wang | Zendy; Xin-Jun Liu | Zendy; Qianmei Zhou | Zendy; Jia Du | Zendy; Tianling Zhang | Zendy; Yi-Yu Lu | Zendy; Shi-Bing Su | Zendy

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Ginsenoside Rb1 Reduces Isoproterenol-Induced Cardiomyocytes ApoptosisIn VitroandIn Vivo

Author(s) -

Xiufeng Wang,

Xin-Jun Liu,

Qianmei Zhou,

Jia Du,

Tianling Zhang,

Yi-Yu Lu,

Shi-Bing Su

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/454389

Subject(s) - panax notoginseng , apoptosis , in vivo , ginseng , chemistry , in vitro , ginsenoside , pharmacology , caspase 3 , western blot , protein kinase c , microbiology and biotechnology , kinase , biology , programmed cell death , medicine , biochemistry , pathology , alternative medicine , gene

Cardiomyocytes apoptosis can lead to heart failure. Conventional and alternative drugs, such as Chinese herbal remedies, have been developed to target cardiomyoblast cells apoptosis. In this study, we investigated the effects of ginsenoside Rb1 (Rb1), an active compound, which is isolated from Notoginseng and Ginseng on isoproterenol-(ISO-) induced apoptosis in rat cardiomyocytes and its mechanism in vivo and in vitro . Rb1 reduced the ISO-induced apoptosis in rat cardiomyocytes and H9c2 cells. The effect of Rb1 was significantly suppressed by H89 (inhibitor for PKA), but not by C-1 (inhibitor for PKC). Based on in-cell blot analysis, the ISO-induced PKA and PKC expressions were decreased by Rb1, which was inhibited by H89, but not by C-1. The expressions of caspase-3 and caspase-9 were decreased after treatment with both ISO and Rb1, but with no change for caspase-8. Our results indicated that Rb1 reducing ISO-induced rat cardiomyocytes apoptosis may be involved in PKA and caspase-9 pathways.

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