α-Mangostin fromCratoxylum arborescens(Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study | Zendy

Heyam Mohamed Ali Sidahmed | Zendy; Siddig İbrahim Abdelwahab | Zendy; Syam Mohan | Zendy; Mahmood Ameen Abdulla | Zendy; Manal Mohamed Elhassan Taha | Zendy; Najihah Mohd Hashim | Zendy; Amir Hadi | Zendy; Jamunarani S. Vadivelu | Zendy; Mun Fai Loke | Zendy; Mawardi Rahmani | Zendy; Maizatulakmal Yahayu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

α-Mangostin fromCratoxylum arborescens(Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study

Author(s) -

Heyam Mohamed Ali Sidahmed,

Siddig İbrahim Abdelwahab,

Syam Mohan,

Mahmood Ameen Abdulla,

Manal Mohamed Elhassan Taha,

Najihah Mohd Hashim,

Amir Hadi,

Jamunarani S. Vadivelu,

Mun Fai Loke,

Mawardi Rahmani,

Maizatulakmal Yahayu

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/450840

Subject(s) - chemistry , lipid peroxidation , antioxidant , traditional medicine , ulcer index , nitric oxide , glutathione , pharmacology , ethanol , biochemistry , gastric mucosa , medicine , stomach , enzyme , organic chemistry

Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer. This study evaluated the antiulcerogenic mechanism(s) of α -mangostin (AM) in a rat model of ulcer. AM is a prenylated xanthone derived through biologically guided fractionation of C. arborescens . Rats were orally pretreated with AM and subsequently exposed to acute gastric lesions induced by ethanol. Following treatment, ulcer index, gastric juice acidity, mucus content, histological and immunohistochemical analyses, glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and nonprotein sulfhydryl groups (NP-SH) were evaluated. The anti- Helicobacter pylori , cyclooxygenase-2 (COX-2) inhibitory effect, and antioxidant activity of AM were also investigated in vitro . AM (10 and 30 mg/kg) inhibited significantly ( P < 0.05) ethanol-induced gastric lesions by 66.04% and 74.39 %, respectively. The compound induces the expression of Hsp70, restores GSH levels, decreases lipid peroxidation, and inhibits COX-2 activity. The minimum inhibitory concentration (MIC) of AM showed an effective in vitro anti- H. pylori activity. The efficacy of the AM was accomplished safely without presenting any toxicological parameters. The results of the present study indicate that the antioxidant properties and the potent anti- H. pylori , in addition to activation of Hsp70 protein, may contribute to the gastroprotective activity of α -mangostin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research