Synthesis andIn VitroAntitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline | Zendy

Yongli Zhang | Zendy; Xiangsheng Wang | Zendy; Wei Fang | Zendy; Xiaoyan Cai | Zendy; Fujiang Chu | Zendy; Xiangwen Liao | Zendy; Jiazheng Lu | Zendy

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Synthesis andIn VitroAntitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline

Author(s) -

Yongli Zhang,

Xiangsheng Wang,

Wei Fang,

Xiaoyan Cai,

Fujiang Chu,

Xiangwen Liao,

Jiazheng Lu

Publication year - 2013

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/2013/437134

Subject(s) - chemistry , schiff base , apoptosis , annexin , semicarbazone , in vitro , phenanthroline , ligand (biochemistry) , cancer cell , mtt assay , cell cycle , derivative (finance) , pi , stereochemistry , cell cycle checkpoint , microbiology and biotechnology , biochemistry , receptor , cancer , crystallography , medicine , biology , financial economics , economics

Two oxovanadium(IV) complexes of [VO(msatsc)(phen)], ( 1 ) (msatsc = methoxylsalicylaldehyde thiosemicarbazone, phen = phenanthroline) and its novel derivative [VO (4-chlorosatsc)(phen)], ( 2 ) (4-chlorosatsc = 4-chlorosalicylaldehyde thiosemicarbazone), have been synthesized and characterized by elemental analysis, IR, ES-MS, 1 H NMR, and magnetic susceptibility measurements. Their antitumor effects on BEL-7402, HUH-7, and HepG2 cells were studied by MTT assay. The antitumor biological mechanism of these two complexes was studied in BEL-7402 cells by cell cycle analysis, Hoechst 33342 staining, Annexin V-FITC/PI assay, and detection of mitochondrial membrane potential (ΔΨm). The results showed that the growth of cancer cells was inhibited significantly, and complexes 1 and 2 mainly caused in BEL-7402 cells G0/G1 cell cycle arrest and induced apoptosis. Both 1 and 2 decreased significantly the ΔΨm, causing the depolarization of the mitochondrial membrane. Complex 2 showed greater antitumor efficiency than that of complex 1 .

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