Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers | Zendy

Yongxiang Zhang | Zendy; Xinmin Liu | Zendy; Yizhong Lu | Zendy; Wang Jin-cai | Zendy; Tingfang Dong | Zendy; Xiaohong Liu | Zendy

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Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers

Author(s) -

Yongxiang Zhang,

Xinmin Liu,

Yizhong Lu,

Wang Jin-cai,

Tingfang Dong,

Xiaohong Liu

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/430459

Subject(s) - mesoporous silica , chemistry , biocompatibility , mesoporous material , nanotechnology , drug delivery , nanoparticle , drug carrier , drug , organic chemistry , pharmacology , materials science , catalysis , medicine

In this study, heparinized multifunctional mesoporous silica nanoparticles were successfully synthesized and characterized. The new material not only maintains intrinsic functions of bare magnetic and fluorescent mesoporous silica materials such as targeting, imaging, and sustained release of drugs, but also generates several novel activities such as the enhancement of biocompatibility, selective loading drugs, and dual loading of anticancer drug and bFGF, rendering it a promising candidate to be used as a multifunctional carrier. The strategy of combination of multifunctional mesoporous silica materials with bioactive molecules could be a new effective approach to improve their capabilities in the drug delivery. © 2013 Yongxiang Zhang et al.

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