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Obesity is a metabolic disorder characterized by chronic inflammation and dyslipidemia and is a strong predictor for the development of hypertension, diabetes mellitus, and cardiovascular disease. This study examined the antiobesity effect of an ethanol extract of Corni Fructus containing formulation (CDAP), which is a combination of four natural components: Corni Fructus, Dioscoreae Rhizoma, Aurantii Fructus Immaturus, and Platycodonis Radix. The cellular lipid content in 3T3-L1 adipocytes was assessed by Oil Red O staining. Expressions of peroxisome proliferator-activated receptor-  γ   (PPAR-  γ  ), CCAAT/enhancer-binding protein-  α   (C/EBP-  α  ), and lipin-1 were determined by real-time RT-PCR. Western blot was used to determine the protein levels of PPAR-  γ  , C/EBP-  α  , and AMP-activated protein kinase-  α   (AMPK-  α  ). The CDAP extract suppressed the differentiation of 3T3-L1 adipocytes by downregulating cellular induction of PPAR-  γ  , C/EBP-  α  , and lipin-1. The CDAP extract also significantly upregulated phosphorylation of AMPK-  α  . An  in vivo  study showed that CDAP induced weight loss in mice with high-fat-diet-induced obesity. These results indicate that CDAP has a potent anti-obesity effect due to the inhibition of adipocyte differentiation and adipogenesis.

Corni Fructus Containing Formulation Attenuates Weight Gain in Mice with Diet-Induced Obesity and Regulates Adipogenesis through AMPK