Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs | Zendy

Yaowalak Srisuwan | Zendy; Yodthong Baimark | Zendy

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Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs

Author(s) -

Yaowalak Srisuwan,

Yodthong Baimark

Publication year - 2013

Publication title -

advances in materials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.356

H-Index - 42

eISSN - 1687-8442

pISSN - 1687-8434

DOI - 10.1155/2013/412458

Subject(s) - fibroin , materials science , fourier transform infrared spectroscopy , scanning electron microscope , polymer blend , nuclear chemistry , chemical engineering , controlled release , dissolution , drug delivery , silk , polymer , composite material , nanotechnology , chemistry , copolymer , engineering

Silk fibroin (SF)/alginate blend films have been prepared for controlled release of tetracycline hydrochloride, an antimicrobial model drug. The blend films were analysed by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and UV-vis spectroscopy. The functional groups of the SF/alginate blends were monitored from their FTIR spectra. The homogeneity of the blend films was observed from SEM images. The dissolution and film transparency of the blend films depended on the SF/alginate blend ratio. The in vitro drug release profile of the blend films was determined by plotting the cumulative drug release versus time. It was found that the drug release significantly decreased as the SF/alginate blend ratio increased. The results demonstrated that the SF/alginate blend films should be a useful controlled-release delivery system for water-soluble drugs

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