DNA Binding and Cleavage Activities of Na[B(Glu)(OH)2]·2H2O, Na[B(Cit)(OH)2]·2H2O, Li[B(Sal)(OH)2], and Mg[B(Sal)(OH)2]·2H2O Complexes | Zendy

Ali Arslantaş | Zendy; Alparslan Kadir Devrim | Zendy; Mert Sudağıdan | Zendy; Dursun Ali Köse | Zendy

Open Access

DNA Binding and Cleavage Activities of Na[B(Glu)(OH)₂]·2H₂O, Na[B(Cit)(OH)₂]·2H₂O, Li[B(Sal)(OH)₂], and Mg[B(Sal)(OH)₂]·2H₂O Complexes

Author(s) -

Ali Arslantaş,

Alparslan Kadir Devrim,

Mert Sudağıdan,

Dursun Ali Köse

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/406161

Subject(s) - chemistry , cleavage (geology) , dna , stereochemistry , biochemistry , geotechnical engineering , fracture (geology) , engineering

The interaction of some previously reported complexes Na[B(Glu)(OH)2]·2H2O, Na[B(Cit)(OH)2]·2H2O, Li[B(Sal)(OH)2], and Mg[B(Sal)(OH)2]·2H2O with cattle genomic DNA (CG-DNA) was investigated using UV absorption, viscosity measurements, and fluorescence studies. These complexes interact with DNA through the intercalative mode of binding. In addition, the DNA cleavage activity of the complexes in presence of H2O2 was determined using agarose gel electrophoresis. All complexes exhibit moderate ability of cleavage to the DNA.

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