Noncoding RNAs in Neurodegenerative Diseases | Zendy

Shraddha D. Rege | Zendy; Thangiah Geetha | Zendy; Satyanarayana R. Pondugula | Zendy; Claire A. Zizza | Zendy; Catherine M. Wernette | Zendy; Jeganathan Ramesh Babu | Zendy

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Noncoding RNAs in Neurodegenerative Diseases

Author(s) -

Shraddha D. Rege,

Thangiah Geetha,

Satyanarayana R. Pondugula,

Claire A. Zizza,

Catherine M. Wernette,

Jeganathan Ramesh Babu

Publication year - 2013

Publication title -

isrn neurology

Language(s) - English

Resource type - Journals

eISSN - 2090-5513

pISSN - 2090-5505

DOI - 10.1155/2013/375852

Subject(s) - microrna , neurogenesis , biology , neuroscience , biogenesis , long non coding rna , neural stem cell , non coding rna , biomarker , disease , rna , gene , stem cell , genetics , medicine , pathology

Noncoding RNAs are widely known for their various essential roles in the development of central nervous system. It involves neurogenesis, neural stem cells generation, maintenance and maturation, neurotransmission, neural network plasticity, formation of synapses, and even brain aging and DNA damage responses. In this review, we will discuss the biogenesis of microRNA, various functions of noncoding RNA's specifically microRNAs (miRNAs) that act as the chief regulators of gene expression, and focus in particular on misregulation of miRNAs which leads to several neurodegenerative diseases as well as its therapeutic outcome. Recent evidences has shown that miRNAs expression levels are changed in patients with neurodegenerative diseases; hence, miRNA can be used as a potential diagnostic biomarker and serve as an effective therapeutic tool in overcoming various neurodegenerative disease processes.

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