Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature | Zendy

Carlos Zagalo | Zendy; Francesca Pierdomenico | Zendy; José Cabeçadas | Zendy; Pedro David Santos | Zendy

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Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature

Author(s) -

Carlos Zagalo,

Francesca Pierdomenico,

José Cabeçadas,

Pedro David Santos

Publication year - 2013

Publication title -

case reports in oncological medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.173

H-Index - 7

eISSN - 2090-6714

pISSN - 2090-6706

DOI - 10.1155/2013/370179

Subject(s) - lymphoma , pregnancy , malignancy , chromosomal translocation , medicine , cancer research , oncology , immunology , gene , biology , genetics

Burkitt's lymphoma (BL) is an aggressive B-cell malignancy with very high proliferation rate, more common in males than females. Here, we describe a case of Burkitt's lymphoma in a 24-week pregnant woman with cervical and abdominal involvement. The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. Supportive treatment was administered until early delivery, after which the patient was treated according to protocol LMB96. Pregnancy and tumorogenesis share some important events such as immunologic tolerance, angiogenesis, and editing the host immune response. Little is known about the relationship between these events in pregnancy and in tumorogenesis.

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