Adsorptive Cathodic Stripping Voltammetric Determination of Cefoperazone in Bulk Powder, Pharmaceutical Dosage Forms, and Human Urine | Zendy

Vu Dang Hoang | Zendy; Dao Thi Huyen | Zendy; Phan Hong Phuc | Zendy

Open Access

Adsorptive Cathodic Stripping Voltammetric Determination of Cefoperazone in Bulk Powder, Pharmaceutical Dosage Forms, and Human Urine

Author(s) -

Vu Dang Hoang,

Dao Thi Huyen,

Phan Hong Phuc

Publication year - 2013

Publication title -

journal of analytical methods in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.407

H-Index - 25

eISSN - 2090-8865

pISSN - 2090-8873

DOI - 10.1155/2013/367914

Subject(s) - chemistry , chromatography , supporting electrolyte , adsorptive stripping voltammetry , cefoperazone , hanging mercury drop electrode , cathodic stripping voltammetry , adsorption , square wave , voltammetry , nuclear chemistry , electrochemistry , electrode , organic chemistry , biochemistry , imipenem , antibiotic resistance , antibiotics , physics , voltage , quantum mechanics

The electroreduction behaviour and determination of cefoperazone using a hanging mercury drop electrode were investigated. Cyclic voltammograms of cefoperazone recorded in universal Britton-Robinson buffers pH 3–6 exhibited a single irreversible cathodic peak. The process was adsorption-controlled. Britton-Robinson buffer 0.04 M pH 4.0 was selected as a supporting electrolyte for quantitative purposes by differential pulse and square wave adsorptive cathodic stripping voltammetry. The experimental voltammetric conditions were optimized using Central Composite Face design. A reduction wave was seen in the range from −0.7 to −0.8 V. These voltammetric techniques were successfully validated as per ICH guidelines and applied for the determination of cefoperazone in its single and sulbactam containing powders for injection and statistically comparable to USP-HPLC. They were further extended to determine cefoperazone in spiked human urine with no matrix effect.

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