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The expressions of reference genes used in gene expression studies are assumed to be stable under most circumstances. However, studies had demonstrated that genes assumed to be stably expressed in a species are not necessarily stably expressed in other organisms. This study aims to evaluate the likelihood of genus-specific reference genes for liver using comparable microarray datasets from  Spermophilus lateralis  and  Spermophilus tridecemlineatus . The coefficient of variance (CV) of each probe was calculated and there were 178 probes common between the lowest 10% CV of both datasets ( n  = 1258). All 3 lists were analysed by NormFinder. Our results suggest that the most invariant probe for  S. tridecemlineatus  was 02n12, while that for  S. lateralis  was 24j21. However, our results showed that Probes 02n12 and 24j21 are ranked 8644 and 926 in terms of invariancy for  S. lateralis  and  S. tridecemlineatus  respectively. This suggests the lack of common liver-specific reference probes for both  S. lateralis  and  S. tridecemlineatus . Given that  S. lateralis  and  S. tridecemlineatus  are closely related species and the datasets are comparable, our results do not support the presence of genus-specific reference genes.

isrn bioinformatics

Transcriptome Analysis of <i>Spermophilus lateralis</i> and <i>Spermophilus tridecemlineatus</i> Liver Does Not Suggest the Presence of Spermophilus-Liver-Specific Reference Genes

Transcriptome Analysis of Spermophilus lateralis and Spermophilus tridecemlineatus Liver Does Not Suggest the Presence of Spermophilus-Liver-Specific Reference Genes