Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor | Zendy

Yuta Yamada | Zendy; Tetsuya Fujimura | Zendy; Satoru Takahashi | Zendy; Kenichi Takayama | Zendy; Tomohiko Urano | Zendy; Taro Murata | Zendy; Daisuke Obinata | Zendy; Yasuyoshi Ouchi | Zendy; Yukio Homma | Zendy; Satoshi Inoue | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor

Author(s) -

Yuta Yamada,

Tetsuya Fujimura,

Satoru Takahashi,

Kenichi Takayama,

Tomohiko Urano,

Taro Murata,

Daisuke Obinata,

Yasuyoshi Ouchi,

Yukio Homma,

Satoshi Inoue

Publication year - 2013

Publication title -

advances in urology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 30

eISSN - 1687-6377

pISSN - 1687-6369

DOI - 10.1155/2013/348438

Subject(s) - immunohistochemistry , germ cell tumors , clinical significance , amyloid precursor protein , medicine , testicular cancer , testicular germ cell tumor , cell , pathology , germ cell , messenger rna , cancer research , cancer , biology , gene , genetics , disease , chemotherapy , alzheimer's disease

. The biological role of amyloid precursor protein (APP) is not well understood, especially in testicular germ cell tumors (TGCTs). Therefore, we aimed to investigate the immunoreactivity (IR) and expression of APP in TGCTs and evaluated its clinical relevance. Materials and Methods . We performed an analysis of immunohistochemistry and mRNA expression of APP in 64 testicular specimens and 21 snap-frozen samples obtained from 1985 to 2004. We then evaluated the association between APP expression and clinicopathological status in TGCTs. Results . Positive APP IR was observed in 9.8% (4/41) of seminomatous germ cell tumors (SGCTs) and 39.1% (9/23) of nonseminomatous germ cell tumors (NGCTs). NGCTs showed significantly more cases of positive IR ( P = 0.00870) and a higher mRNA expression level compared with those of SGCTs ( P = 0.0140). Positive APP IR was also significantly associated with α -fetoprotein ( α FP) elevation ( P = 0.00870) and venous invasion ( P = 0.0414). Conclusion . We observed an elevated APP expression in TGCTs, especially in NGCTs. APP may be associated with a more aggressive cancer in TGCTs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research