Ligation of Fe(III) and Mn(II) Complexes by Bithiourea and Their Biological Activity | Zendy

Johnson F. Adediji | Zendy; Saliu Alao Amolegbe | Zendy; Sheriff Adewuyi | Zendy; Caroline A. Akinremi | Zendy; Yetunde C. Oyeniran | Zendy; B. O. Afolayan | Zendy

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Ligation of Fe(III) and Mn(II) Complexes by Bithiourea and Their Biological Activity

Author(s) -

Johnson F. Adediji,

Saliu Alao Amolegbe,

Sheriff Adewuyi,

Caroline A. Akinremi,

Yetunde C. Oyeniran,

B. O. Afolayan

Publication year - 2013

Publication title -

isrn inorganic chemistry

Language(s) - English

Resource type - Journals

ISSN - 2314-470X

DOI - 10.1155/2013/329508

Subject(s) - chemistry , ligand (biochemistry) , denticity , metal , nuclear chemistry , conductance , biological activity , infrared spectroscopy , elemental analysis , inorganic chemistry , in vitro , organic chemistry , biochemistry , receptor , mathematics , combinatorics

Complexes of Fe(III) and Mn(II) with bithiourea were synthesized and characterised by elemental analysis, magnetic measurements, infrared spectroscopy, UV/visible, thin layer chromatography, and conductance measurements. The IR showed that the ligand coordinates through C=S and N–H donor atoms and hence a bidentate. The antimicrobial activity of the complexes formed has been tested and compared with bithiourea at different concentrations in order to obtain some quantitative information about their biological activity towards microorganism. Metal complexes were found to show better activities as compared to the ligand and the standard drug used as control. In vivo toxicological studies showed that the complexes were not toxic at the dosage level administered.

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